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KMID : 0363620060270040062
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Journal of Korean Oriental Medicine
2006 Volume.27 No. 4 p.62 ~ p.73
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Effects of Saenghyul-dan (SHD) on the Myelosuppression Induced by 5-Fluorouracil
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Lee Gi-Joon
Yoo Hwa-Seung
Cho Chong-Kwan
Cho Jung-Hyo
Lee Yeon-Weol
Son Chang-Gue
Yoon Dam-Hee
Lee Nam-Heon
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Abstract
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Objective : This study aimed to investigate the effect of SHD on myelosuppression using an animal model for therapeutic evidence supporting clinical positive results.
Methods : After determining the optimal concentration of 5-FU as 300 mg/kg for developing the mouse model, ICR mice or BALB/c mice were administered with SHD, and several blood parameters, including hematopoietic cytokines, colony forming activity and histological findings, were examined to evaluate the effects.
Results : SHD restored the WBC and hemoglobin, and showed effects on maintaining body weight, producing GM-CSF and IL-3 and stem cell colony forming activity in accordance with histological relative entirety on bone marrow.
Conclusion : SHD is an herbal drug having therapeutic effects on myelosuppression. Thus, it could be prescribed to cancer patients undergoing chemo-therapies or radio-therapies in the process of cancer treatment.
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KEYWORD
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Saenghyul-dan (sh{={e}}ngxi{v{e}}ed{={a}}n), myelosuppression
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